This is supposed to be juvey made in nano particle size for absorption.
But I cannot remember the post ~ anyone? Google comes up with nothing

---

jenny32301

Thanks Barbie, I just ordered it!

---

jenny32301

There was a paper a few years ago on topical hyaluronan fragments having a beneficial effect on photoaged skin, but benefits were seen only for a certain molecular weight. If the fragments are too small (< 50000 Da) they won't do anything. If they are too big (> 400000 Da) they will not penetrate. You can get one of the right weight hyaluronate powders from one of the DIY cosmetics sellers, it's about $7/oz, and since the appropriate use rate is around 1% that oz will last a long time. Ref is: Kaya et al., Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism, PLoS Medicine, December 2006 | Volume 3 | Issue 12 | e493, free online. If you opt for DIY you will also need a preservative.

Just to let you know, nano particles are under fire for possible danger to the entire immune system because the particles are so small that they travel through the body to places where you probably don't want them.

---

If anybody knows of any orthopedic doctors, in Boston or Concord MA area who are conversant in FEMORAL ACETEBULAR IMPINGMENT, please let me know.

Cancel above request. My hip is now too far gone. Need a total hip replacement.

My brother-in-law is a molecular biologist whose been written up in Time magazine, so he has credentials. I hd a similar discussion with him about a year ago on the safety of nanotech. He filled me in a bit. Nanotechnology is not new. Did you know that Milk of Magnesia was the first nanotech product, before it was called nano? Yup, that's right. Don't believe everything you read about nanotech, it may end up saving lives and curing diseases one day (if handled responsibility and in the right hands).

SAS sells HA that you can mix up a solution, she also sells it ready-made. I used it for a while and it is very hydrating but that's about the best I can say about it.

Nanoparticles are probably safe, too. The biggest concern is with physical sunscreen particles:
http://www.ncbi.nlm.nih.gov/pubmed/20156837

There is a "rule of 500" that molecules of molecular weight > 500 Daltons penetrate the skin only with great difficulty and rarely with few exceptions (hyaluronic is one of the exceptions, probably because of the way it is folded/clumped) and that is a safe "native" molecule.

The newer nonphysical sunscreen filters (mexoryls, tinosorbs, etc.) were designed to have a much greater size than this and just sit on the skin.

But many other active ingredients have much lower molecular weights. These have not been shown to promote appreciable health hazards.

The only ingredients I think it is very prudent to avoid are phthalates and acrylamides (and derivatives). I was shocked when I learned that a dermal filler was developed using acrylamides (bio-alcamid). I'm pretty sure that it will be removed from the market eventually.